5812 South Ellis Ave.
Chicago, IL 60637
Speaker: Jary Delgado
Title: Posttranscriptional and Posttranslational Molecular Mechanisms Regulating Excitatory Synapse Function.
Abstract:Activity-dependent changes in synaptic strength is a key molecular mechanism thought to be required for the storage of long-term memories through the brain. However, our understanding of the multitude of molecular mechanisms regulating excitatory synaptic strength is limited. In this talk, I will present evidence for three molecular mechanisms regulating excitatory synaptic plasticity and the stability of surface AMPAR at synapses. Firstly, I will show evidence for the role of proline-directed protein phosphorylation in the regulation of PSD-95 stability within postsynaptic spines. Secondly, I will show evidence from high-resolution single-particle imaging studies highlighting how alterations in the scaffolding proteins alter the diffusion of surface ionotropic AMPA receptors. Thirdly, I will show evidence for the effects of N6-methyladenosine (m6A), a novel epitranscriptional modification of mRNA, on dendritically localized mRNAs (e.g., PSD-95) and striatal learning and memory. This talk will highlight a multilevel analysis and tool-development program aimed at understanding the dynamics of synaptic proteins to draw relationships between molecular events at synapses and their effect on excitatory synaptic strength.