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Post Doc.
February 12th, 2019 | Second Tuesdays I 12:30 p.m.
Billings P-403

5812 South Ellis Ave.
Chicago, IL 60637
United States

Upcoming Meetings: 

February 12th:

Speaker: Jary Delgado 

Title: Posttranscriptional and Posttranslational Molecular Mechanisms Regulating Excitatory Synapse Function.

Abstract:Activity-dependent changes in synaptic strength is a key molecular mechanism thought to be required for the storage of long-term memories through the brain. However, our understanding of the multitude of molecular mechanisms regulating excitatory synaptic strength is limited. In this talk, I will present evidence for three molecular mechanisms regulating excitatory synaptic plasticity and the stability of surface AMPAR at synapses. Firstly, I will show evidence for the role of proline-directed protein phosphorylation in the regulation of PSD-95 stability within postsynaptic spines. Secondly, I will show evidence from high-resolution single-particle imaging studies highlighting how alterations in the scaffolding proteins alter the diffusion of surface ionotropic AMPA receptors. Thirdly, I will show evidence for the effects of N6-methyladenosine (m6A), a novel epitranscriptional modification of mRNA, on dendritically localized mRNAs (e.g., PSD-95) and striatal learning and memory. This talk will highlight a multilevel analysis and tool-development program aimed at understanding the dynamics of synaptic proteins to draw relationships between molecular events at synapses and their effect on excitatory synaptic strength.

March 12th
April 9th
May 14th
June 11th