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Post Doc.
February 12th, 2019 | Second Tuesdays I 12:30 p.m.
Billings P-403

5812 South Ellis Ave.
Chicago, IL 60637
United States

Upcoming Meetings: 

February 12th:

Speaker: Jary Delgado 

Title: Posttranscriptional and Posttranslational Molecular Mechanisms Regulating Excitatory Synapse Function.

Abstract:Activity-dependent changes in synaptic strength is a key molecular mechanism thought to be required for the storage of long-term memories through the brain. However, our understanding of the multitude of molecular mechanisms regulating excitatory synaptic strength is limited. In this talk, I will present evidence for three molecular mechanisms regulating excitatory synaptic plasticity and the stability of surface AMPAR at synapses. Firstly, I will show evidence for the role of proline-directed protein phosphorylation in the regulation of PSD-95 stability within postsynaptic spines. Secondly, I will show evidence from high-resolution single-particle imaging studies highlighting how alterations in the scaffolding proteins alter the diffusion of surface ionotropic AMPA receptors. Thirdly, I will show evidence for the effects of N6-methyladenosine (m6A), a novel epitranscriptional modification of mRNA, on dendritically localized mRNAs (e.g., PSD-95) and striatal learning and memory. This talk will highlight a multilevel analysis and tool-development program aimed at understanding the dynamics of synaptic proteins to draw relationships between molecular events at synapses and their effect on excitatory synaptic strength.


March 12th
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May 14th
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