Theory Club
May 24th:10:00am, SBRI J-400C
Speaker: Stephanie Palmer, PhD
2019 Andros Lecture
May 29th: 5:00pm, KCBD 1103
Speaker:Bonnie Bassler, PhD - HHMI Investigator and Chair of the Molecular Biology Department at Princeton
Title: “Quorum-Sensing Communication: From Viruses to Bacteria to Eukaryotes
Theory Club
May 31st:10:00am, BSLC 002 (note: different location)
Speaker: Tatiana Engel, PhD - Cold Spring Harbor
Title: Discovering dynamic states of neural populations
Abstract: Neural responses and behavior are influenced by internal brain states, such as arousal or task context. Ongoing variations of these internal states affect global patterns of neural activity, giving rise to apparent variability of neural responses under the same experimental conditions. Uncovering dynamics of internal states from data proved difficult with traditional techniques based on trial-averaged responses of single neurons. In this talk, I will describe our recent work leveraging multi-electrode neural activity recordings and computational models to reveal internal-state dynamics of neural populations during perception and goal-directed behavior. I will show how endogenous fluctuations of ensemble neural activity in the primate visual cortex depend on the global arousal and selective attention. The spatiotemporal structure of these fluctuations accounts for correlated variability across cortical layers and columns. I will then present a broadly applicable, non-parametric framework for discovering neural population dynamics directly from the data without a priori model assumptions. The framework uncovers dynamic computations from large-scale neural recordings with single-neuron, single-spike resolution.
